Rooted in solid foundation of design techniques on high-speed circuit, detector front-end circuit, and data acquisition (DAQ) systems, the Real-time Tech Laboratory (RTLab) mainly focuses on the investigation of key techniques related with high-performance real-time information processing systems. To meet the requirement of real-time systems in large-scale scientific experiment facilities, RTLab investigated, in recent years, pico-second time measurement techniques, novel energy signal measurement methods for multi-pixel position sensitive detectors, and 3D positioning schemes for interaction point determination in detectors. The related algorithms and their acceleration by hardware were investigated as well. In addition to fields of large scale scientific experiment facility, these techniques were applied in other domains, such as nuclear medicine imaging, infrared imaging, TOF camera, LiDAR and quantum key distribution (QKD) systems. By the combination of FPGA technique and ASIC design technique, we are currently investigating new time readout driven data acquisition methods to overcome the bottleneck problem of high performance and high integration readout electronics for large scale particle imaging detectors. We are also investigating new signal processing techniques based on neural networks, artificial intelligence, and applying them to real-time DAQ systems of imaging devices. At the same time, the techniques of super high-speed (>10Gbps) true random number generators are being investigated in our lab to satisfy the requirement of real-time random number generation for GHz-QKD and other emerging encryption systems.